The Amy K Walker Lab:

Department of Molecular Medicine

UMASS Medical School

Walker, A.K. 1-Carbon Cycle Metabolites Methylate Their Way to Fatty Liver (2017) Trends Endocrinol Metab. 28: 63-72.

PMID: 27789099

Walker, AK. Germ Cells Need Folate to Proliferate. (2016) Dev Cell. 11:8-9.

PMID: 27404353

Smulan, L.J.,; Ding, W.; Freinkman, E.; Gujja, S., Edwards, Y.J.K.; Walker, A.K. Cholesterol-indendent SREBP-1 maturation is linked to ARF1 inactivation. (2016) Cell Rep 6:9-18.

PMID: 27320911

PMCID: PMC4934023

Ding W, Smulan LJ, Hou NS, Taubert S, Watts JL, Walker AK. s-Adenosylmethionine Level Govern Innate Immunity through Distinct Methylation-Dependent Pathways. (2015)  Cell Metabolism 22:633-45.

PMID: 26321661

PMCID: PMC4598287

Amy K. Walker and Anders M. Näär. SREBPs: regulators of cholesterol/lipids as therapeutic targets in metabolic disorders, cancers and viral diseases. (2012) Clinical Lipidology, 7:27-36

Amy K. Walker*, Rene L. Jacobs, Jennifer L. Watts, Veerle Rottiers, Karen Jiang, Deirdre M. Finnegan, Toshi Shioda, Malene Hansen, Fajun Yang, Lorissa Niebergall, Dennis M. Vance, Anne C. Hart, and Anders M. Näär*. A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell. 2011 Nov 11;147(4):840-52. PMID: 22035958

PMCID: PMC3384509

Maria Dimitriadi, James N. Sleigh*, Amy K. Walker*, Howard C-H. Chang, Anindya Sen, Geetika Kalloo, Jevede Harris, Tom Barsby, Melissa B. Walsh, John S. Satterlee, Chris Li, David Van Vactor, Spyros Artavanis-Tsakonas, Anne C. Hart. Conserved genes act as modifiers of invertebrate SMN loss of function defects. (2010) PLOS Genetics 6(10): e1001172 . *These authors contributed equally to this work and are listed alphabetically.

PMID:  21124729

PMCID: PMC2965752

Walker A.K., Yang F., Jiang K., Ji J.Y., Watts J.L., Purushotham A,. Boss O., Hirsch M.L., Ribich S., Smith J.J., Israelian K., Westphal C.H., Rodgers J.T., Shioda T., Elson S.L., Mulligan P., Najafi-Shoushtari H., Black J.C., Thakur J.K., Kadyk L.C., Whetstine J.R., Mostoslavsky R., Puigserver P., Li X., Dyson N.J., Hart A.C., Näär A.M. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. (2010) Genes and Development 24:1403-17

PMID: 2059523

PMCID:  PMC2895199

Blackwell T.K. and Walker A.K. OMA-Gosh, Where’s That TAF? (2008) Cell 135(1) pp. 18 - 20.

PMID:  18854150

Walker, A.K., Boag, P.R., Blackwell, T.K. Transcription reactivation steps stimulated by oocyte maturation in C. elegans. (2007) Developmental Biology (304)382-93.

PMID: 17291483

Yang, F., Vought, B.W., Satterlee, J.S., Walker, A.K., Sun, Z.-Y.J., Watts, J.L., DeBeaumont, R., Saito, R.M., Hyberts, S.G., Yang, S., Macol, C. Iyer, L., Tjian, R., van den Heuvel, S., Hart, A.C., Wagner, G. and Näär, A.M. An ARC/Mediator subunit required for SREBP gene activation and regulation of cholesterol and fatty acid homeostasis. (2006)  Nature 7103:700-4.

PMID: 16799563

Walker, A.K. and Blackwell T.K. Transcriptional Mechanisms. (2006) Worm Book (ed. The C. elegans community).

PMID: 18050436

PMCID: PMC4781191

Wang, J.C, Walker, A.K., Blackwell, T.K., and Yamamoto, K.R. The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis. (2004) J Biol Chem 279: 29270 – 29277.

PMID: 15073178

Walker, A.K., Shi Y., and Blackwell, T.K. An extensive transcriptional requirement for C. elegans TAF-1 in embryonic  transcription . (2004) J Biol Chem 279:15339-47.

PMID: 14726532

Blackwell, T.K. and Walker, A.K. Transcriptional Elongation:  TLKing to chromatin.  (2003) Current  Biology 13:915-916.

PMID: 14654017

Takagi, T., Walker, A.K., Diehn, F., Sawa, C., Takase, Y, Blackwell, T.K., and Buratowski, S. C. elegans mRNA capping enzyme: in vitro and in vivo characterization. (2003) J Biol Chem 278:14174-14184.

PMID: 12576476

Walker, A.K., and Blackwell, T.K. A broad but restricted requirement for TAF-5 (hTAFII100) for embryonic transcription in C. elegans. (2003) J Biol Chem 278:6181- 6186.

PMID: 12458202

Shim, EY, Walker, A.K., Shi Y., and Blackwell, T.K. CDK9/CyclinT (P-TEFb) is Required for Two Post-initiation Pathways for Transcription in the C. elegans embryo. (2002) Genes and Development 16:2135-2146.

PMID: 12183367

PMCID: PMC186450

Shim, EY, Walker, A.K., and Blackwell, T.K. Broad requirement for the Mediator Component RGR-1 for Transcription and Pol II CTD phosphorylation in the C. elegans embryo. (2002) J Biol Chem 277(34):30413-30416.

PMID: 12089139

Blackwell, T. K., and Walker, A.K. Getting the right dose of repression. (2002) Genes and Development 16: 769-772.

PMID: 11937484

Walker A.K., Rothman J.H., Shi Y., and Blackwell T.K. Distinct requirements for C.elegans TAFIIs in early embryonic transcription. (2001) EMBO J. 20(18):5269-5279.

PMID: 11566890

PMCID: PMC125634

Walker A.K., See R., Batchelder C., Kophengnavong T., Gronniger J.T., Shi Y., and Blackwell T.K. A conserved transcription motif suggesting functional parallels between Caenorhabditis elegans SKN-1 and Cap'n'Collar-related basic leucine zipper proteins. (2000) J Biol Chem. 275(29): 22166-71.

PMID: 10764775

Smardova, J., Walker, A., Morrison, L. and P.J. Enrietto Mutations in the carboxy terminus of v-rel alter the expression of cellular genes. (1995) Oncogene 10:2017- 2026.

PMID: 7761102

Walker A. K. and P.J. Enrietto Analysis of the role of v-rel in the transcriptional regulation of high mobility group protein 14. (1996) Oncogene, 12: 2515-2525.

PMID:  8700510

Walker, A. and P.J. Enrietto Regulatable Chimeric Oncogenes. (1995) Methods in Enzymology 254: 469-30

PMID: 8531707

Boehmelt, G., Walker, A., Mellitzer, G. Beug, H., Zenke, M., and P.J. Enrietto Hormone regulated v-rel estrogen receptor fusion protein: Reversible induction of cell transformation and cellular gene expression. (1992) EMBO J 11: 4641-4652.

PMID: 1425595

PMCID: PMC557040