The Amy K Walker Lab:

Department of Molecular Medicine

UMASS Medical School



We study how metabolites act as signals to control gene expression and lipid accumulation

The Walker lab uses worms, cells and mice to study how metabolites like the methyl-donor SAM or the methylated phospholipid PC regulate gene expression, the activity of the lipogenic transcription factor SREBP-1 and how bacterial metabolites can affect lipid accumulation in multicellular animals.